Rioprostil in the treatment of duodenal erosions

Thirty outpatients with erosions of the duodenal bulb unrelated to peptic ulcer were randomly allocated to an 8-week treatment regimen with either rioprostil, 200 micrograms b.d., or with sucralfate, 1 g t.i.d. At endoscopic control complete disappearance of duodenal erosions was found in 57.2% of rioprostil-treated patients and in 64.3% of patients treated with sucralfate. The difference was not statistically significant. The two drugs were shown to be significantly and equally effective in inducing relief of dyspeptic symptoms. No intestinal side effects were observed during treatment with rioprostil.