[Metabolic changes in liver tissue damage and the effect of nutrition on liver regeneration]

The present work reviews basic changes occurring in metabolism of carbohydrates, lipids and amino acids of an organism with liver injury and after resection of 70% of liver tissue. On the background of mentioned changes, the effect of individual energetic substrates and amino acids on the course of liver regeneration is discussed. Literature data and our proper results allow us to preclude that administration of only carbohydrates is impeding liver recovery. According to our observation, the liver regeneration after partial hepatectomy as well as the restoration of toxically damaged liver tissue may be favorably enhanced by infusion of lipid emulsion (Intralipid). The infusion of balanced amino acid solution (8% Nutramin) rather depresses the development of liver regeneration. Parenteral administration of amino acid solution enriched with branched chain amino acids (valine, leucine, isoleucine) has a favorable effect on the onset of liver regeneration after partial hepatectomy compared with glucose and of commercial amino acid solution (8% Nutramin). Probable mechanisms of inhibitory effect of glucose and favorable action of lipid emulsion infusions as well as branched chain amino acids on the initiation of liver regeneration are discussed.