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Exercise and sleep in aging: emphasis on serotonin.

M O Melancon¹, D Lorrain², I J Dionne¹

¹Research center on aging, Sherbrooke geriatric university institute-health and social services center, 1036, Belvedere South, J1H 4C4 Sherbrooke, QC, Canada; Department of kinanthropology, faculty of physical and sport education, university of Sherbrooke, 2500, boulevard de l'Université, J1K 2R1 Sherbrooke, QC, Canada.

Pathologie-Biologie

|August 9, 2014

Summary

Aerobic exercise may improve sleep by boosting serotonin activity, but excessive training can cause insomnia. Understanding the serotonin-exercise-sleep connection is crucial for addressing sleep disorders in aging populations.

Keywords:

5-HT 5-hydroxytryptamine Acides aminés Activité physique Activité sérotonergique Advancing age Amino acids CNS Cerveau Elderly Locomotor activity Neurotransmetteurs Neurotransmitters Personnes âgées Physical activity Prolonged exercise SNC Vieillissement

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Area of Science:

Neuroscience
Sleep Science
Exercise Physiology

Background:

Aging is linked to reduced central serotonin activity, potentially causing sleep disorders.
Serotonin plays a key role in promoting sleep through inhibition of neural networks.
Aerobic exercise is known to positively impact sleep, but the mechanisms are complex.

Purpose of the Study:

To explore the role of serotonin in the relationship between aerobic exercise and sleep.
To investigate how exercise influences central serotonergic pathways and their effect on sleep-wake regulation.

Main Methods:

Review of existing literature on exercise, serotonin, and sleep.
Analysis of studies on acute and chronic exercise effects on brain serotonin concentrations.
Examination of research on tryptophan supplementation and depletion effects on sleep.

Main Results:

Exercise acutely increases forebrain serotonin, but this effect diminishes post-exercise.
Adequate exercise may adapt serotonergic networks, while excessive training can lead to insomnia.
Exercise can accelerate biological clock resynchronization, and serotonin's effect on wakefulness is biphasic.

Conclusions:

Acute aerobic exercise might enhance sleep by increasing serotonergic projections.
Further research is needed to fully elucidate serotonin's role in the exercise-sleep axis.
Serotonin modulation through exercise presents a potential avenue for managing sleep disturbances.