Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

43.8K
Overview
43.8K
Vaccine Production01:23

Vaccine Production

129
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
129

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune biomarkers, profiles, and responses: a vaccine ontology perspective.

Journal of biomedical semantics·2026
Same author

Towards Healthy Aging through Semantic Enrichment.

CEUR workshop proceedings.·2026
Same author

Vaxjo 2.0: An ontology- and large language model-powered knowledge base of vaccine adjuvants and mechanisms.

Frontiers in cellular and infection microbiology·2026
Same author

Profiling of human lung and gut microbiomes in different conditions of chronic obstructive pulmonary disease using ontology-based evidence synthesis and reasoning.

Frontiers in cellular and infection microbiology·2026
Same author

BERTopic-driven term extraction from biomedical texts toward ontology population: evaluating vaccine ontology with Plotkin's vaccines corpus.

Journal of biomedical semantics·2026
Same author

VO: The Vaccine Ontology.

Scientific data·2026

Related Experiment Video

Updated: Apr 26, 2026

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
09:04

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency

Published on: May 11, 2020

12.8K

DNAVaxDB: the first web-based DNA vaccine database and its data analysis.

Rebecca Racz, Xinna Li, Mukti Patel

    BMC Bioinformatics
    |August 9, 2014
    PubMed
    Summary
    This summary is machine-generated.

    DNAVaxDB is the first public database for DNA vaccines, plasmid vectors, and antigens. It curates, stores, and analyzes experimental data, aiding DNA vaccine research and development.

    More Related Videos

    Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells
    12:54

    Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

    Published on: May 19, 2023

    2.6K
    Facilitating the Analysis of Immunological Data with Visual Analytic Techniques
    10:58

    Facilitating the Analysis of Immunological Data with Visual Analytic Techniques

    Published on: January 2, 2011

    9.5K

    Related Experiment Videos

    Last Updated: Apr 26, 2026

    In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
    09:04

    In Vitro ELISA Test to Evaluate Rabies Vaccine Potency

    Published on: May 11, 2020

    12.8K
    Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells
    12:54

    Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

    Published on: May 19, 2023

    2.6K
    Facilitating the Analysis of Immunological Data with Visual Analytic Techniques
    10:58

    Facilitating the Analysis of Immunological Data with Visual Analytic Techniques

    Published on: January 2, 2011

    9.5K

    Area of Science:

    • Vaccinology
    • Bioinformatics
    • Immunology

    Background:

    • DNA vaccine research has expanded significantly since the 1990s.
    • A need exists for a centralized, curated repository of DNA vaccine data.
    • Existing data is fragmented across numerous studies and sources.

    Purpose of the Study:

    • To develop and present DNAVaxDB, the first publicly accessible web-based database for DNA vaccines.
    • To curate, store, and analyze experimentally verified DNA vaccines, plasmid vectors, and protective antigens.
    • To facilitate advanced DNA vaccine research and development through accessible data.

    Main Methods:

    • Data curation from peer-reviewed articles and reliable resources.
    • Development of a web-based platform with user-friendly query and visualization interfaces.
    • Standardized data storage using the Vaccine Ontology (VO) for interoperability.

    Main Results:

    • DNAVaxDB contains over 400 DNA vaccines, 370 protective antigens, and 140 plasmid vectors.
    • Identified specific plasmid usage patterns (e.g., pCMVi-UB for bacterial, pCAGGS for viral vaccines).
    • Analyzed antigen localization trends and vaccination regimens across various diseases, including parasitic and cancer applications.

    Conclusions:

    • DNAVaxDB provides a vital, comprehensive resource for DNA vaccine information.
    • The database facilitates comparative analysis of vaccine components and strategies.
    • It is poised to accelerate future DNA vaccine research and development efforts.