Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

46.1K
Overview
46.1K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.4K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.4K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

1.1K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.6K
Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

2.3K
Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
2.3K
Adrenergic Receptors: ɑ Subtype01:31

Adrenergic Receptors: ɑ Subtype

2.7K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-associated B-cells predict coronary events in humans and aggravate murine atherosclerosis.

Cardiovascular research·2026
Same author

Cathepsin S Deficiency Prevents Chronic Stress-Related Renal Remodeling and Dysfunction in a Mouse 5/6 Nephrectomy Injury Model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Eosinophil extracellular traps: heterogeneity of their stimuli, components, and functions.

Trends in cell biology·2026
Same author

Innate immune responses following myocardial ischemia and reperfusion: Evidence, mechanisms, and translational challenges.

Pharmacology & therapeutics·2026
Same author

Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy.

European heart journal·2026
Same author

Mast cells in cardiovascular disease: Fibrosis, angiogenesis and atherogenesis.

Progress in cardiovascular diseases·2025

Related Experiment Video

Updated: Apr 26, 2026

Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

14.6K

Mast cells as effectors in atherosclerosis.

Ilze Bot1, Guo-Ping Shi2, Petri T Kovanen2

  • 1From the Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (I.B.); Department of Medicine, Brigham and Woman's Hospital and Harvard Medical School, Boston, MA (G.-P.S.); and Wihuri Research Institute, Helsinki, Finland (P.T.K.). i.bot@lacdr.leidenuniv.nl.

Arteriosclerosis, Thrombosis, and Vascular Biology
|August 9, 2014
PubMed
Summary

Mast cells, immune cells involved in allergies, also contribute to cardiovascular diseases by promoting atherosclerotic plaque instability. Targeting mast cells may offer new strategies for preventing heart attacks and strokes.

Keywords:
atherosclerosisleukocytesmast cells

More Related Videos

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

9.8K
Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

11.8K

Related Experiment Videos

Last Updated: Apr 26, 2026

Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

14.6K
Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

9.8K
Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

11.8K

Area of Science:

  • Immunology
  • Cardiovascular Biology
  • Pathophysiology

Background:

  • Mast cells are key immune cells involved in allergic reactions and host defense.
  • Emerging evidence highlights mast cell involvement in cardiovascular diseases, particularly atherosclerosis.
  • Activated mast cells release mediators that impact vessel wall integrity and inflammation.

Purpose of the Study:

  • To review current knowledge on mast cell function in cardiovascular diseases.
  • To explore the role of mast cells in atherosclerotic plaque progression and destabilization.
  • To discuss potential therapeutic strategies targeting mast cells for cardiovascular disease prevention.

Main Methods:

  • Literature review of studies on mast cells and cardiovascular diseases.
  • Analysis of mast cell mediators and their effects on the vessel wall.
  • Discussion of existing and potential therapeutic interventions.

Main Results:

  • Mast cells contribute to cardiovascular diseases through mediators like chymase and tryptase.
  • Activated mast cells promote matrix degradation, apoptosis, and inflammatory cell recruitment.
  • These actions actively contribute to the development and progression of cardiovascular diseases.

Conclusions:

  • Mast cells play a significant role in the pathophysiology of cardiovascular diseases.
  • Targeting mast cells presents a promising therapeutic avenue for preventing acute cardiovascular syndromes.
  • Further research into mast cell-specific therapies is warranted.