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First report on the lipid profile late after kawasaki disease in Iranian children

Seyyed-Naserredin Mostafavi1, Elham Barzegar2, Nayereh Siyah Manssori3

  • 1Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Pediatrics, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

International Journal of Preventive Medicine
|August 9, 2014
PubMed

Insights

Kawasaki disease (KD) patients did not show significantly different lipid profiles compared to controls. However, over a third of KD children had abnormal lipid values, highlighting the need for regular monitoring.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Health
  • Immunology

Background:

  • Kawasaki disease (KD) may predispose children to abnormal lipid profiles, increasing long-term atherosclerosis risk.
  • Assessing late-stage lipid profiles in KD survivors is crucial for understanding long-term cardiovascular implications.

Purpose of the Study:

  • To determine and compare the lipid profiles of children with a history of Kawasaki disease (KD) to healthy controls.
  • To evaluate potential long-term effects of KD on cardiovascular risk factors like lipid levels, blood pressure, and BMI.

Main Methods:

  • A historical cohort study involving 32 children: 16 with uncomplicated KD history and 16 age-matched healthy controls (siblings or cousins).
  • Fasting serum levels of total cholesterol (TC), HDL-C, LDL-C, and triglycerides (TG) were measured.
  • Blood pressure and body mass index (BMI) were also assessed and compared between groups.

Main Results:

  • No statistically significant differences were observed in mean systolic blood pressure, diastolic blood pressure, BMI, TG, TC, HDL-C, or LDL-C between KD patients and controls.
  • Abnormal lipid values were found in 6 of 16 KD patients and 7 of 16 controls.

Conclusions:

  • Iranian children with a history of Kawasaki disease (KD) likely do not have significantly different lipid profiles compared to healthy controls.
  • Given that over one-third of KD subjects exhibited dyslipidemia, periodic lipid monitoring is strongly recommended for these patients.
Abstract

Keywords:
AtherosclerosisIranKawasaki diseasechildrenlipid profile

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