Liver transplantation in older adults

Summary

Liver transplantation is a vital treatment for end-stage liver disease, with older adults comprising 15% of recipients. Post-transplant care, including medication adherence and follow-up, is crucial for preventing complications and graft rejection.

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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