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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

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Updated: Apr 26, 2026

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

Leptin receptor makes its mark on MSCs.

Yumi Matsuzaki¹, Yo Mabuchi², Hideyuki Okano³

¹Department of Life Science Laboratory of Tumor Biology, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan.

|August 9, 2014

Summary

This summary is machine-generated.

Researchers identified the Leptin Receptor as a key marker for mesenchymal stem/stromal cells (MSCs). This discovery aids in the prospective identification and in vivo fate mapping of bone marrow MSCs for better understanding of the hematopoietic niche.

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Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

Area of Science:

Hematology
Stem Cell Biology
Cellular Biology

Background:

Mesenchymal stem/stromal cells (MSCs) play a crucial role in the hematopoietic niche.
Identifying functional markers for MSCs is essential for understanding their physiological roles.
Current markers do not fully correlate with MSC functions.

Purpose of the Study:

To identify a reliable marker for the prospective isolation of bone marrow MSCs.
To enable in vivo fate mapping of MSCs within the hematopoietic niche.
To advance the understanding of MSCs' contribution to hematopoiesis.

Main Methods:

Utilized a combination of techniques for cell identification and characterization.
Performed in vivo fate mapping studies.
Correlated marker expression with cellular function.

Main Results:

Identified the Leptin Receptor (LepR) as a specific marker for bone marrow MSCs.
Demonstrated that LepR+ cells are crucial for maintaining the hematopoietic stem cell niche.
Showcased the utility of LepR for prospective isolation and tracking of MSCs.

Conclusions:

Leptin Receptor is a valuable marker for identifying and studying functional bone marrow MSCs.
This finding facilitates further research into MSC biology and therapeutic applications.
The identification of LepR advances the study of the hematopoietic niche and stem cell regulation.