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Egg and breast milk based nitrogen sources compared.

J W Puntis1, P A Ball, M A Preece

  • 1Institute of Child Health, University of Birmingham.

Archives of Disease in Childhood
|October 1, 1989
PubMed
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Comparing two parenteral nutrition formulas in infants, Vaminolact (breast milk-like amino acids) showed better plasma amino acid profiles than Vamin 9 glucose, reducing risks of high phenylalanine and tyrosine levels.

Area of Science:

  • Neonatal nutrition
  • Parenteral nutrition
  • Biochemistry

Background:

  • Parenteral nutrition (PN) is crucial for infants unable to receive enteral feeding.
  • Optimizing amino acid profiles in PN solutions is essential for infant health.
  • Current PN formulations may not perfectly mimic human breast milk.

Purpose of the Study:

  • To compare the effects of two different amino acid solutions on plasma amino acid profiles in parenterally fed infants.
  • To evaluate growth and nitrogen retention in infants receiving either Vamin 9 glucose or Vaminolact.
  • To assess the safety and efficacy of a breast milk-like amino acid profile in PN.

Main Methods:

  • A randomized controlled trial involving 14 parenterally fed infants.
  • Infants received either Vamin 9 glucose (egg protein-based) or Vaminolact (breast milk-like amino acid profile).

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  • Diets were identical apart from the amino acid source; growth and nitrogen retention were monitored over six days.

    • Main Results:

    • No significant differences in growth or nitrogen retention were observed between the two groups.
    • Infants receiving Vamin 9 glucose exhibited abnormal plasma amino acid profiles.
    • Significantly higher concentrations of phenylalanine and tyrosine were noted in the Vamin 9 glucose group compared to the Vaminolact group.

    Conclusions:

    • Vaminolact, with an amino acid profile similar to breast milk, improves plasma amino acid concentrations during parenteral nutrition.
    • Using breast milk-like amino acid profiles in PN can mitigate risks of hyperphenylalaninaemia and hypertyrosinaemia.
    • Vaminolact offers a potentially safer alternative for parenteral nutrition in infants.