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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

160
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
169
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.9K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.9K
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.2K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

309
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Nanosize drug delivery system.

Biswajit Mukherjee1

  • 1Department of Pharmaceutical Technology Jadavpur University Kolkata-700032 India. biswajit55@yahoo.com.

Current Pharmaceutical Biotechnology
|August 10, 2014
PubMed
Summary
This summary is machine-generated.

Nanotechnology revolutionizes drug delivery by creating targeted, effective treatments. Nanosize drug delivery systems enhance drug efficacy, reduce toxicity, and enable precise treatment at the molecular level.

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Area of Science:

  • Nanotechnology and Nanomedicine
  • Materials Science for Drug Delivery
  • Biotechnology and Molecular Targeting

Background:

  • Nanomaterials offer unprecedented potential for drug delivery, enabling molecular-level disease treatment.
  • Nanotechnology provides tools for fine-tuned therapies, enhancing drug efficacy and reducing toxicity.
  • Nanodimensional systems alter biodistribution, concentrating therapeutic agents in target tissues.

Discussion:

  • Diverse nanocarriers (nanocrystals, liposomes, dendrimers, viral capsids) formulate bioactive molecules, including nucleic acids and proteins.
  • Surface modifications (PEGylation, antibody conjugation) enable precise targeting of diseased cells.
  • Nanotechnology addresses challenges in delivering drugs across the blood-brain barrier and for chronic diseases like cancer and diabetes.

Key Insights:

  • Nanosize drug delivery systems achieve versatile tissue targeting, controlled release, and reduced side effects.
  • Nanoparticles and nanoliposomes are crucial for cancer chemotherapy, diagnosis, and gene delivery.
  • Nanotechnology facilitates targeted delivery of vaccines and therapeutic agents to specific cells.

Outlook:

  • Nanocomposites hold promise for personalized medicine, bone repair, and cartilage regeneration.
  • Future drug therapy will be significantly influenced by nanoscale drug delivery systems.
  • Ongoing research focuses on developing reliable, efficient, and safe nanostructural drug delivery systems.