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Intrinsic heart function and food intake.

H Kelbaek1

  • 1Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Denmark.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|August 1, 1989
PubMed
Summary
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This review explains how the body

Area of Science:

  • Physiology
  • Cardiovascular System
  • Human Physiology

Background:

  • Hemodynamic responses to physiological stimuli are complex.
  • Autonomic nervous system influences cardiac function significantly.
  • Postprandial cardiovascular adjustments are unique in humans.

Purpose of the Study:

  • To review hemodynamic changes during exercise, autonomic blockade, and after food intake.
  • To elucidate the role of intrinsic cardiac mechanisms and autonomic control.
  • To understand human-specific cardiovascular adaptations.

Main Methods:

  • Review of existing literature on hemodynamic responses.
  • Analysis of left ventricular (LV) volume and heart rate changes.
  • Comparison of responses under different conditions: exercise, autonomic blockade, and postprandial state.

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Main Results:

  • Mild exercise primarily affects LV volume; heart rate increases cardiac output in moderate to heavy exercise.
  • Intrinsic cardiac mechanisms maintain cardiac output post-autonomic blockade via LV dilation.
  • Postprandial increase in cardiac output is mainly due to increased stroke volume from LV dilation, influenced by vasoactive peptides.
  • Autonomic nervous system significantly modulates postprandial and exercise-induced hemodynamic changes.

Conclusions:

  • The autonomic nervous system plays a crucial role in mediating hemodynamic adjustments to food intake and exercise.
  • Intrinsic cardiac mechanisms compensate for autonomic blockade, but are less effective during exercise.
  • Human cardiovascular responses to food intake involve unique neuro-peptide interactions affecting cardiac output.