Related Experiment Video

Updated: Apr 26, 2026

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

3.6K

The genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains

Annetrude J G de Mooij-van Malsen1, Eneda Pjetri2, Martien J Kas3

  • 1Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands; Institute of Physiology, CAU Kiel, Germany.

European Journal of Pharmacology
|August 10, 2014
PubMed

Insights

Animal research is crucial for developing new central nervous system (CNS) disorder drugs. This review highlights integrated approaches in behavioral neuroscience, pharmacology, and genetics, offering insights into neurobehavioral traits for psychiatric disorders.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics
  • Psychiatry

Background:

  • Animal models are vital for central nervous system (CNS) disorder drug discovery.
  • Berend Olivier's career has significantly advanced CNS drug discovery through novel methodologies.
  • Contributions span behavioral neuroscience, pharmacology, and (epi)genetics.

Purpose of the Study:

  • To review and present integrated approaches in CNS drug discovery.
  • To highlight insights into genetic and epigenetic regulation of neurobehavioral traits.
  • To showcase the impact of Berend Olivier's work in psychiatric disorder research.

Main Methods:

  • Review of integrated approaches in behavioral neuroscience.
  • Application of pharmacological methodologies in drug testing.
  • Utilizing (epi)genetic analyses for neurobehavioral trait investigation.

Main Results:

  • Identification of novel drug candidates for CNS disorders.
  • New understanding of genetic and epigenetic factors in psychiatric disorders.
  • Demonstration of productive collaboration leading to significant insights.

Conclusions:

  • Integrated approaches combining diverse scientific fields are effective for CNS drug discovery.
  • Genetic and epigenetic factors play a key role in neurobehavioral traits relevant to psychiatric disorders.
  • Berend Olivier's contributions have substantially impacted the field of CNS research.
Keywords:
BehaviorDrug targetsEndophenotypesHumanMousePsychiatry

More Related Videos

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

1.8K
Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans07:35

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

Published on: February 4, 2014

10.9K

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
119
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.3K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
156
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
241
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.4K