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Updated: Apr 26, 2026
10:05
In vivo 19F MRI for Cell Tracking
Published on: November 25, 2013
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(19)F applications in drug development and imaging - a review
Dorota Bartusik1, David Aebisher2
1Southern Polytechnic State University, Department of Biology and Chemistry, 1100 South Marietta Parkway, Marietta, GA 30060, USA.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 10, 2014
Summary
Fluorine-19 (19F) labeled drugs combined with magnetic resonance imaging (MRI) offer new ways to track drug distribution in the body. This approach can help improve drug delivery and combat drug resistance.
Area of Science:
- Pharmacotherapy
- Medical Imaging
- Drug Delivery
Background:
- Controlling drug efficacy in vivo requires innovative strategies.
- Fluorine-19 ((19)F) applications in pharmacotherapy are advancing.
- Tracking drug biodistribution non-invasively is crucial for effective treatment.
Purpose of the Study:
- To review methods for incorporating (19)F into pharmaceuticals.
- To explore the use of (19)F magnetic resonance imaging (MRI) for drug tracking.
- To highlight how (19)F MRI can address drug resistance by improving drug delivery.
Main Methods:
- Formation of carbon-fluorine (C-F) bonds for drug labeling.
- Development of drug fluorine oil-water emulsions.
- Utilizing non-invasive (19)F MRI techniques for biodistribution studies.
Main Results:
- Successful incorporation of (19)F into pharmaceutical compounds.
- Demonstrated ability to track drug biodistribution using (19)F MRI.
- Potential for improved drug delivery strategies.
Conclusions:
- (19)F labeling and MRI provide a powerful tool for in vivo drug monitoring.
- These methods offer a promising avenue to overcome drug resistance.
- (19)F MRI can guide the development of more effective drug delivery systems.
![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)
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