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Updated: Apr 26, 2026
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Digestive perianastomotic ulcerations and Crohn's disease
Marie-Louise Frémond1, Jérome Viala2, Xavier Tréton3
1Assistance Publique-Hôpitaux de Paris, Services des Maladies Digestives et Respiratoires de l'enfant, Service de Chirurgie Digestive et Service de Cytologie et Pathologie, Hôpital Robert Debré, 75019 Paris, France.
Background And Aims:
Digestive perianastomotic ulcerations (DPAU) have been occasionally reported as late complications of neonatal or childhood surgery.
Methods:
We report here a series of 14 new cases.
Results:
Cases were revealed by severe anemia, diarrhea, abdominal pain and growth failure in average 11.5 years after surgery. Ulcerations were most often multiple (n=11), located on the upper part of ileocolonic anastomoses (n=12) and difficult to treat. No granulomas were seen but lymphoid follicles were frequent. In addition, either ASCA or ANCA were positive in 4/9 tested patients and 8/11 genotyped patients exhibited a NOD2 mutation (P<0.0002 when compared to French healthy controls).
Conclusion:
Altogether, these findings argue for common physiopathological features between DPAU and Crohn's disease and for a prospective follow-up of selected operated children to explore the early events involved in gut inflammatory lesions.
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