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Obstructive sleep apnea syndrome: a risk factor for Stanford's type B aortic dissection
Xuemin Zhang1, Tao Zhang2, Xiaoming Zhang1
1Department of Vascular Surgery, Peking University People's Hospital, Beijing, China.
Annals of Vascular Surgery
|August 10, 2014
Summary
Obstructive sleep apnea syndrome (OSAS) is common in patients with aortic dissection (AD). This study found OSAS is independently linked to Stanford Type B AD, suggesting it should be considered in clinical management.
Area of Science:
- Cardiology
- Sleep Medicine
- Vascular Surgery
Background:
- Obstructive sleep apnea syndrome (OSAS) is a potential risk factor for aortic dissection (AD).
- The independent association and prevalence of OSAS in AD patients require further investigation.
Purpose of the Study:
- To determine the prevalence of OSAS in patients with Stanford Type B AD.
- To assess the independence of the association between OSAS and AD, controlling for confounders.
Main Methods:
- A cross-sectional study compared 82 patients with Stanford Type B AD to 116 controls.
- Sleep studies (Berlin questionnaire, polysomnography) were conducted. Multivariate analyses identified associated factors.
- A prospective follow-up assessed AD incidence in controls with OSAS.
Main Results:
- OSAS was more frequent in AD patients (81.7%) than controls (67.2%).
- AD patients exhibited higher apnea-hypopnea and oxygen desaturation indices, and lower SaO2.
- OSAS was independently associated with Stanford Type B AD (OR 1.063, P=0.020).
Conclusions:
- OSAS is highly prevalent and independently associated with Stanford Type B AD.
- Clinicians should consider OSAS comorbidity in patients with AD.
- Further research is needed on therapeutic strategies for coexisting AD and OSAS.
