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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Serum adiponectin and markers of endothelial dysfunction in stable angina pectoris patients undergoing coronary
Anna Lisowska1, Piotr Lisowski2, Malgorzata Knapp1
1Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
Insights
Adiponectin and CD146 levels are lower in coronary artery disease patients before and after coronary artery bypass grafting (CABG). These markers increased post-CABG but remained lower than in healthy individuals, suggesting their role in endothelial dysfunction.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Endothelial Function
Background:
- Endothelial dysfunction (ED) is a known complication following coronary artery bypass grafting (CABG).
- Identifying novel markers for ED is crucial for patient management.
Purpose of the Study:
- To investigate adiponectin as a potential novel marker for ED after CABG.
- To explore the relationship between adiponectin and new ED markers (CD146, thrombomodulin) and established markers (Von Willebrand factor).
Main Methods:
- Study included 45 coronary artery disease (CAD) patients undergoing elective CABG.
- Measurements of adiponectin, CD146, thrombomodulin, and Von Willebrand factor were taken before and 3 months after surgery.
- Comparison with a control group of healthy volunteers.
Main Results:
- Adiponectin and CD146 levels were significantly lower in CAD patients pre-CABG compared to controls.
- A significant increase in adiponectin and CD146 was observed 3 months post-CABG.
- Adiponectin correlated with VWF, thrombomodulin, CD146, and graft number post-CABG.
- CD146 correlated with adiponectin, VWF activity, and statin therapy.
Conclusions:
- Adiponectin and CD146 may serve as novel indicators of endothelial cell dysfunction in CAD patients undergoing CABG.
- While levels improve post-CABG, adiponectin remains lower than in healthy individuals, unlike CD146 which normalizes.
Purpose:
It has been established that endothelial dysfunction (ED) occurs after coronary artery bypass grafting (CABG). The aim of the study was to assess whether adiponectin may act as a novel marker of ED and its potential relations with new markers of ED: novel cell adhesion molecule CD146, a natural anti-thrombin glycoprotein - thrombomodulin (TM) and the well-established ED marker - Von Willebrand factor (VWF) in coronary artery disease (CAD) patients undergoing CABG.
Material/Methods:
45 CAD patients undergoing elective CABG were included in the study.
Results:
In the study group the concentration of adiponectin and CD146 before the surgery were significantly lower than in the control group - 6.06 μg/ml ± 3.06 vs. 19.0 μg/ml ± 6.4 and 303.2 ng/ml ± 28.7 vs. 328.1 ng/ml ± 22.6 (p<0.05). Significant increase of adiponectin and CD146 concentration 3 months after CABG vs. before the surgery was found. Adiponectin concentration 3 months after CABG correlated with VWF, TM, CD146, and a number of grafts. CD146 before and 3 months after CABG correlated significantly with adiponectin, VWF activity as well as the statins therapy after the surgery.
Conclusions:
In CAD patients undergoing CABG new markers of endothelial cell dysfunction as adiponectin and CD146 are significantly lower compared to healthy volunteers. Significant increase in adiponectin and CD146 concentration 3 months after CABG vs. before the surgery was found. However adiponectin concentrations 3 months after CABG were still significantly lower compared to healthy individuals, whereas CD146 concentration returned to the values comparable to the control.
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