No association between plasma adiponectin levels and central auditory function in adults

Area of Science:

• Endocrinology
• Auditory Neuroscience
• Public Health

Background:

• Adiponectin's protective role is known in cardiometabolic and peripheral auditory disorders.
• Its influence on central auditory function remains largely unexplored.

Purpose of the Study:

• To investigate the association between plasma adiponectin levels and central auditory function in adults.
• To determine if adiponectin impacts the pitch pattern sequence (PPS) score.

Main Methods:

• Recruited 297 adults with normal or symmetrical sensorineural hearing loss and normal cognition.
• Utilized multivariate linear regression to analyze plasma adiponectin concentrations against PPS scores.
• Adjusted for covariates including age, gender, waist circumference, and comorbidities.

Main Results:

• No significant association was found between plasma adiponectin concentrations and PPS scores after adjusting for multiple variables (p=0.563).
• Excluding waist circumference from the model did not alter the lack of significant association (p=0.855).

Conclusions:

• Plasma adiponectin levels are not significantly associated with the pitch pattern sequence (PPS) score in adults.
• Further investigation into the mechanisms of obesity-related central auditory dysfunction is warranted.