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Published on: February 15, 2022
Ocular toxicity and functional vision recovery in a patient treated with hydroxychloroquine
Francisco Jorge Rodríguez-Hurtado1, José Antonio Sáez-Moreno2, José Manuel Rodríguez-Ferrer3
1Servicio de Oftalmología, Hospital Virgen de las Nieves, Granada, España.
Case Report:
We report the case of a 64-year-old woman with rheumatoid arthritis and Sjögren's syndrome, treated during 48 months with hydroxychloroquine that was removed after an ophthalmological evaluation showed bilateral vision loss associated with paracentral scotoma in the visual field, fundoscopic macular pigmentary changes, and severely impaired central multifocal electrorretinogram (mfERG). Twelve months after treatment withdrawal, visual acuity and central mfERG had surprisingly improved. This is an unusual case of functional recovery after treatment withdrawal. We consider that central mfERG is a more sensitive test than pattern electrorretinogram in the detection of retinal toxicity and functional vision recovery after hydroxychloroquine treatment cessation.
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