Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nursing Clinical Information System01:27

Nursing Clinical Information System

1.3K
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
1.3K
Clinical Trials01:16

Clinical Trials

10.2K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.2K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.7K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.7K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.4K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.4K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

645
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
645

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Xenotransplantation: Injustice, Harm, and Alternatives for Addressing the Organ Crisis.

The Hastings Center report·2025
Same author

Individual difference factors that predict evaluations and acceptance of authorized concealment for the reduction of nocebo side effects.

Patient education and counseling·2025
Same author

Clinical trials are not the solution to inequities in cancer care.

Gynecologic oncology·2025
Same author

Are Patients With Cancer Best Managed in a Clinical Trial?

JAMA·2024
Same author

The Use of Authorized Concealment to Minimize Nocebo Side Effects: A Survey of US Public Attitudes.

Psychotherapy and psychosomatics·2023
Same author

Ethical Outreach for Rural Cancer Care in the United States: Balancing Access With Optimal Clinical Outcomes.

JCO oncology practice·2023
Same journal

On the Dangers of Cancer Exceptionalism in Pain Medicine.

Kennedy Institute of Ethics journal·2026
Same journal

Suck It Up and Stay on the Grind: Ethical Considerations Surrounding Trust, Chronic Pain, and the American Workplace.

Kennedy Institute of Ethics journal·2026
Same journal

<i>Morbus Mediterraneus</i>: A Cultural Alibi for an Unequal Pain Burden.

Kennedy Institute of Ethics journal·2026
Same journal

Beyond Words: A Philosophical Analysis of the Linguistic Refractoriness of Chronic Pain.

Kennedy Institute of Ethics journal·2026
Same journal

When "Good-Enough" Treatment Is Not Good Enough: Epistemic Injustice, Pain-Related Motivational Deficit, and Epistemic Deflection in the Treatment of Gynecological Pain.

Kennedy Institute of Ethics journal·2026
Same journal

The Silent Struggle: A Woman's Journey Through Pain.

Kennedy Institute of Ethics journal·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.2K

Clinical research before informed consent.

Franklin G Miller

    Kennedy Institute of Ethics Journal
    |August 12, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Before 1966, clinical research often excluded informed consent, particularly in placebo trials. This historical review examines the ethical landscape of research participation and informed consent development.

    More Related Videos

    Human Egg Maturity Assessment and Its Clinical Application
    08:51

    Human Egg Maturity Assessment and Its Clinical Application

    Published on: August 19, 2019

    20.1K
    Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time
    07:12

    Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time

    Published on: July 1, 2014

    12.7K

    Related Experiment Videos

    Last Updated: Jan 25, 2026

    In Silico Clinical Trials for Cardiovascular Disease
    09:09

    In Silico Clinical Trials for Cardiovascular Disease

    Published on: May 27, 2022

    2.2K
    Human Egg Maturity Assessment and Its Clinical Application
    08:51

    Human Egg Maturity Assessment and Its Clinical Application

    Published on: August 19, 2019

    20.1K
    Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time
    07:12

    Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time

    Published on: July 1, 2014

    12.7K

    Area of Science:

    • Medical Ethics
    • Clinical Research History

    Background:

    • Prior to 1966, clinical research frequently involved patient-subjects without their informed consent for participation.
    • Placebo-controlled trials were common, with subjects often unaware they were in research or receiving a placebo instead of standard or experimental treatment.

    Observation:

    • The moral climate of clinical research before 1966 is illuminated by examining psychiatric research articles from 1966-1967.
    • These articles mark a transitional period from research disguised as care to research requiring consent and disclosure.

    Findings:

    • Historical analysis reveals the ethical evolution of clinical research practices.
    • The study highlights the significance of informed consent in research ethics.

    Implications:

    • Understanding past practices provides perspective on contemporary research ethics.
    • This inquiry sheds light on the conditions under which research without informed consent may be ethically permissible.