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Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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A cuff & a clock.

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    Remote ischemic conditioning (RIC) shows promise for reducing heart attack size and improving outcomes in STEMI patients. Further clinical studies are warranted due to its simplicity, low cost, and safety.

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    Area of Science:

    • Cardiovascular Physiology
    • Ischemic Preconditioning Research

    Background:

    • Ischemic conditioning is a physiological process with over 20 years of demonstrated potential in animal models for reducing myocardial infarction (MI) size.
    • Previous human trials investigating ischemic conditioning have yielded inconclusive results.

    Purpose of the Study:

    • To evaluate the efficacy of remote ischemic conditioning (RIC) in a well-designed clinical trial for ST-elevation myocardial infarction (STEMI) patients.
    • To assess the potential of RIC to reduce mortality and hospitalization for congestive heart failure in STEMI patients.

    Main Methods:

    • A well-designed clinical trial is currently in progress.
    • The trial will enroll a sufficient number of subjects to achieve statistical power.
    • RIC will be administered to STEMI patients in a pre-hospital setting.

    Main Results:

    • The study is designed to demonstrate significant reductions in mortality and heart failure hospitalizations.
    • Preliminary data from animal studies suggest a reduction in MI size.

    Conclusions:

    • Remote ischemic conditioning (RIC) is a simple, low-cost, and safe intervention.
    • Continued clinical investigation in humans is essential to validate the potential benefits of RIC for STEMI patients.