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Updated: Apr 26, 2026

Using Magnetometry to Monitor Cellular Incorporation and Subsequent Biodegradation of Chemically Synthetized Iron Oxide Nanoparticles
Published on: February 27, 2021
Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles
Lijun Wang1, Yue Min, Doudou Xu
1Institute for Medical Science and Technology, College of Medicine, Dentistry and Nursing, University of Dundee, Dundee DD2 1FD, UK. l.y.wang@dundee.ac.uk.
Abstract:
We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.
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