Related Experiment Video
Updated: Apr 26, 2026

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
Published on: March 4, 2017
Pharmacokinetic evaluation of testosterone-loaded nanocapsules in rats
Sougata Jana1, Anusuya Gangopadhaya2, Benoy Brata Bhowmik2
1Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, WB, India.
Abstract:
In the present work, testosterone-loaded alginate nanocapsules were prepared by in situ nanoemulsification-polymer cross-linking method. Drug loading, particle size (diameter), polydispersity index and zeta potential of these alginate nanocapsules were measured 30.22 ± 1.90%, 34.53 ± 1.72 nm, 0.22 ± 0.04 and -5 mV, respectively. The pharmacokinetic evaluation of these nanocapsules was also performed in female Sprague Dawley rats. Cmax, Tmax and AUC0-24 vales were estimated 38.63ng/ml, 2h and 317.93 ng ml(-1) h(-1), respectively. The pharmacokinetic result of testosterone-loaded alginate nanocapsules indicates better bioavailability in comparison with pure testosterone and commercial testosterone injection.
Related Concept Videos
Measurement of Bioavailability: Pharmacokinetic Methods
Measurement of Bioavailability: Pharmacodynamic Methods
Modified-Release Drug Delivery Systems: Bioavailability
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship

