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Circulation of hepatitis A genotype IIIA virus in paediatric patients in central India

P V Barde1, M K Shukla, Ruchi Pathak

  • 1Regional Medical Research Centre for Tribals (ICMR), Jabalpur, India.

The Indian Journal of Medical Research
|August 12, 2014
PubMed

Insights

Hepatitis A virus (HAV) infection is common in children, with genotype III A circulating in Central India. Regular monitoring is crucial for understanding HAV epidemiology and planning interventions.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Hepatitis A virus (HAV) infection is a significant cause of childhood hepatitis, primarily transmitted via the fecal-oral route.
  • While often subclinical in children, HAV infections can lead to severe outcomes, including hospitalization and mortality.

Purpose of the Study:

  • To investigate the prevalence and genetic characteristics of Hepatitis A virus in suspected pediatric cases in Central India.
  • To understand the epidemiological patterns of HAV infection in the region.

Main Methods:

  • Blood samples from HAV-suspected pediatric cases were tested using IgM ELISA and nested Reverse Transcriptase Polymerase Chain Reaction (nRT PCR).
  • HAV RNA-positive nRT PCR products underwent sequencing for phylogenetic analysis.

Main Results:

  • Out of 195 samples, 41 (21%) tested positive for HAV antibodies, with 38 (92%) from the pediatric age group.
  • 32% of pediatric cases were hospitalized.
  • Phylogenetic analysis identified the circulation of HAV genotype III A in Central India.

Conclusions:

  • The study confirms the presence and circulation of Hepatitis A virus genotype III A in Central India, particularly affecting the pediatric population.
  • Regular serological and molecular surveillance is essential for effective HAV epidemiology understanding and intervention strategy development.

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