Related Experiment Video
Updated: Apr 26, 2026

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
Published on: June 16, 2022
Regulation of ELAV/Hu RNA-binding proteins by phosphorylation
Ulrike Bräuer1, Emanuela Zaharieva1, Matthias Soller1
1*School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Abstract:
ELAV (embryonic lethal/abnormal visual system)/Hu proteins comprise a family of highly related neuronal RBPs (RNA-binding proteins) involved in many aspects of mRNA processing. Although they bind to highly similar short sequence motifs, they have acquired diverse functions suggesting that cellular signalling is important for their functional diversification. Indeed, ELAV/Hu proteins harbour many phosphorylatable amino acids. In the present article, we review our current knowledge about phosphorylation of ELAV/Hu proteins and how phosphorylation affects cellular localization of ELAV/Hu proteins and their binding to RNA.
Related Concept Videos
Regulation of Expression at Multiple Steps
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Translational Regulation
Chromatin Structure Regulates pre-mRNA Processing
The chromatin structure, especially...
RNA Polymerase II Accessory Proteins

