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Myocardial serotonin during ischemia under conditions of ischemic preconditioning

S E Naumenko1, T V Latysheva, M A Gilinskii

  • 1Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, NSE2@mail.ru.

Bulletin of Experimental Biology and Medicine
|August 12, 2014
PubMed

We studied the dynamics of interstitial serotonin during local myocardial ischemia under conditions of ischemic preconditioning in Wistar rats. Ischemic preconditioning increased serotonin content in the dialysate (p=0.003). During 30-min ischemia, ischemic preconditioning delayed serotonin increase just before the 20th min of ischemia. Ischemic preconditioning promoted short-term increase in the serotonin level in the myocardial interstitium but followed by prolonged ischemia, it delayed the accumulation of serotonin in the myocardial interstitium.

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