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Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
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[Oxidative stress and longevity; a case-control study].

Ángel Belenguer Varea1, Kheira Mohamed Abdelaziz2, Juan Antonio Avellana Zaragoza1

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Summary

Centenarians exhibit lower oxidative stress (OE) levels, specifically reduced malondialdehyde (MDA) and oxidized proteins (OP), compared to younger elderly individuals. Lower OE indicates a higher likelihood of achieving extreme longevity.

Keywords:
Case-control studyCentenariansCentenariosEstrés oxidativoEstudio de casos y controlesLongevidadLongevityOxidative stress

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Area of Science:

  • Gerontology
  • Biochemistry
  • Longevity research

Background:

  • Human longevity is influenced by genetic and environmental factors, with oxidative stress (OE) potentially playing a key role.
  • The ability to combat OE may be linked to successful aging and exceptional lifespan.
  • This study investigates OE markers in centenarians to understand their role in human longevity.

Purpose of the Study:

  • To compare plasma levels of malondialdehyde (MDA) and oxidized proteins (OP) between centenarians (older than 97 years) and younger elderly individuals (70-80 years).
  • To determine the association between OE levels and extreme longevity.

Main Methods:

  • A population-based case-control study was conducted.
  • Cases were individuals over 97 years old from La Ribera county, Valencia, Spain.
  • Controls were randomly selected individuals aged 70-80 years from the same region.

Main Results:

  • Twenty-eight cases and 31 controls were included in the study.
  • Centenarians had significantly lower plasma levels of MDA and OP compared to controls.
  • Lower quartiles of MDA and OP were associated with a higher odds ratio (OR) of being a centenarian (OR=3.8 for MDA, OR=5.7 for OP).

Conclusions:

  • Oxidative stress levels are lower in centenarians compared to younger elderly individuals.
  • A lower degree of oxidative stress is associated with an increased likelihood of reaching extreme old age.
  • These findings suggest that reduced oxidative stress contributes to human longevity.