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Updated: Apr 26, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Discovery of modulators of HIV-1 infection from the human peptidome
Jan Münch1, Ludger Ständker1, Wolf-Georg Forssmann2
11] Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. [2] Ulm Peptide Pharmaceuticals, Ulm University, 89081 Ulm, Germany.
Abstract:
Almost all human proteins are subject to proteolytic degradation, which produces a broad range of peptides that have highly specific and sometimes unexpected functions. Peptide libraries that have been generated from human bodily fluids or tissues are a rich but mostly unexplored source of bioactive compounds that could be used to develop antimicrobial and immunomodulatory therapeutic agents. In this Innovation article, we describe the discovery, optimization and application of endogenous bioactive peptides from human-derived peptide libraries, with a particular focus on the isolation of endogenous inhibitors and promoters of HIV-1 infection.
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