Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.7K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.7K
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

15
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
15
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

18
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
18
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

23
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
23
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

15
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
15
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

15
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
15

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Target Trial Emulation of Vaccine Effectiveness in 5- to 17-years-olds with Prior SARS-CoV-2 Infection.

Nature communications·2026
Same author

Pilot proteomics study for identifying a pollution exposure signature in firefighters.

Journal of exposure science & environmental epidemiology·2026
Same author

Risk of venous thromboembolism associated with short-term exposure to fine particulate matter (PM<sub>2.5</sub>) and ozone air pollution.

Research and practice in thrombosis and haemostasis·2025
Same author

Age-Related Changes in the Clinical Picture of Long COVID.

Journal of the American Geriatrics Society·2025
Same author

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions.

Frontiers in systems biology·2025
Same author

Intermittent fasting and a no-sugar diet for Long COVID symptoms: a randomized crossover trial.

Scientific reports·2025

Related Experiment Video

Updated: Apr 26, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K

Hypothyroidism as a risk factor for statin intolerance.

Craig D Robison1, Tami L Bair2, Benjamin D Horne3

  • 1Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

Journal of Clinical Lipidology
|August 12, 2014
PubMed
Summary

Hypothyroidism is more common in patients with statin intolerance, particularly in females. Individuals with hypothyroidism are less likely to be prescribed statins long-term, impacting cardiovascular care.

Keywords:
DyslipidemiaEpidemiologyHMG-COA reductase inhibitorsStatin intoleranceStatin rechallengeStatins HypothyroidismSubclinical hypothyroidism

Related Experiment Videos

Last Updated: Apr 26, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K

Area of Science:

  • Cardiology
  • Endocrinology
  • Preventive Medicine

Background:

  • Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) are widely used for cardiovascular benefits.
  • Statin intolerance affects 5% to 20% of patients, posing a challenge in preventive medicine.
  • Understanding the underlying causes of statin intolerance is crucial.

Purpose of the Study:

  • To investigate the association between statin intolerance and hypothyroidism.
  • To examine sex-specific relationships in statin intolerance and hypothyroidism.
  • To analyze subsequent statin rechallenge and prescription patterns.

Main Methods:

  • Utilized electronic medical records from Intermountain Healthcare.
  • Identified 2686 patients with documented statin intolerance and 8103 age/sex-matched controls.
  • Evaluated history of hypothyroidism, development of hypothyroidism, and statin prescription history over 5 years.

Main Results:

  • Hypothyroidism was more prevalent in patients with statin intolerance (30.2%) compared to controls (21.5%).
  • The association was significant in both males (OR 1.29) and females (OR 1.60), with a stronger link in females.
  • Patients with both statin intolerance and hypothyroidism were less likely to remain on statin therapy (HR 0.84).

Conclusions:

  • Hypothyroidism is significantly more prevalent in individuals experiencing statin intolerance, especially in females.
  • Patients with hypothyroidism and statin intolerance show reduced likelihood of continued statin prescription.
  • This highlights a potential link between endocrine status and statin tolerability impacting cardiovascular treatment adherence.