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Lymphocyte homing antagonists in the treatment of inflammatory bowel diseases

Masayuki Saruta1, Konstantinos A Papadakis2

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 3 Chome-25-8 Nishishinbashi, Minato, Tokyo 105-0003, Japan.

Gastroenterology Clinics of North America
|August 12, 2014
PubMed

Lymphocyte homing antagonists represent promising therapeutic agents for the treatment of idiopathic inflammatory bowel disease (IBD). Several critical molecules involved in the recruitment of inflammatory cells in the intestine, including integrins and chemokine receptors, have been successfully targeted for the treatment of IBD. These agents have shown great promise for the induction and maintenance of remission for both Crohn disease and ulcerative colitis. This article discusses currently approved prototypic agents for the treatment of IBD (natalizumab, anti-α4 integrin; vedolizumab, anti-α4β7 integrin), and several other agents in the same class currently under development.

Keywords:
Chemokine receptorsCrohn diseaseEtrolizumabInflammatory bowel diseaseIntegrinsNatalizumabUlcerative colitisVedolizumab

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