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Update on ustekinumab for the treatment of Crohn's disease

Yvette Leung1, Remo Panaccione1

  • 1Division of Gastroenterology, Department of Medicine, University of Calgary, 3280 Hospital Drive Northwest, Calgary, Alberta T2N 4N1, Canada.

Gastroenterology Clinics of North America
|August 12, 2014
PubMed

Despite the success of antitumor necrosis factor (TNF) therapy in Crohn's disease, there remains a need for biologic therapy that targets other immune pathways of disease. Ustekinumab is a fully human monoclonal immunoglobulin antibody that targets the interleukin (IL)-12 and IL-23 shared P40 subunit. It has been studied in 2 phase 2 randomized, double-blind, placebo-controlled trials in Crohn's disease. This article reviews the clinical efficacy and safety data of ustekinumab in Crohn's disease in anticipation of the final results of the phase III development program in moderate to severe Crohn's disease.

Keywords:
Crohn's diseaseInterleukin-12Interleukin-12/23 monoclonal antibodyInterleukin-23PsoriasisUstekinumab

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