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mRNA transport meets membrane traffic
Ralf-Peter Jansen1, Dierk Niessing2, Sebastian Baumann3
1Eberhard Karls Universität Tübingen, Interfaculty Institute of Biochemistry, Hoppe-Seyler-Strasse 4, 72076 Tübingen, Germany.
Trends in Genetics : TIG
|August 12, 2014
Summary
Messenger RNAs (mRNAs) are transported with cellular compartments like the endoplasmic reticulum and endosomes, guided by RNA-binding proteins. This co-transport is crucial for protein localization and function, even in higher eukaryotes.
Area of Science:
- Cell Biology
- Molecular Biology
- Mycology
Background:
- Cellular protein localization relies on active mRNA transport and local translation.
- Emerging evidence links mRNA transport and local translation to membrane trafficking pathways.
Purpose of the Study:
- To investigate the interplay between RNA transport and membrane trafficking in fungal model systems.
- To highlight novel findings on mRNA recognition, co-transport with organelles, and endosome-coupled translation.
Main Methods:
- Studies conducted in fungal model systems.
- Analysis of RNA-binding protein interactions with mRNA.
- Observation of mRNA co-transport with endoplasmic reticulum and endosomes.
Main Results:
- RNA-binding proteins recognize and bind to cargo mRNAs synergistically.
- mRNAs are actively co-transported with membranous cellular compartments, including the endoplasmic reticulum and endosomes.
- A novel mechanism of endosome-coupled translation was identified, essential for septin filamentation.
Conclusions:
- RNA and membrane trafficking are tightly interconnected processes.
- This interplay is vital for spatial protein organization and cellular function.
- Evidence suggests this phenomenon is conserved across eukaryotes, not limited to fungi.
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