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Updated: Apr 26, 2026

Investigating the Phagocytosis of Leishmania using Confocal Microscopy
Published on: July 29, 2021
Innate immunity to Leishmania infection: within phagocytes
Marcela Freitas Lopes1, Ana Caroline Costa-da-Silva1, George Alexandre DosReis1
1Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, Brazil.
Abstract:
Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for monocytes and dendritic cells. This paper addresses recent experimental findings regarding the regulation of Leishmania major infection by these major phagocyte populations. In addition, the role of IL-4 on dendritic cells and monocytes is discussed.
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