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[Preclinical hypothyroidism and disorders of ovarian function]
L Bispink1, W Brändle, C Lindner
1Abteilung für klinische und experimentelle Endokrinologie der Universitäts-Frauenklinik Hamburg-Eppendorf.
Geburtshilfe Und Frauenheilkunde
|October 1, 1989
Summary
Mild hypothyroidism can cause ovarian insufficiency in infertile women. Thyroid function tests are crucial for infertile patients with high prolactin or anovulation.
Area of Science:
- Endocrinology
- Reproductive Medicine
Context:
- Thyroid dysfunction is increasingly recognized as a factor in infertility.
- Subclinical hypothyroidism may impact reproductive outcomes.
- Thyrotropin-releasing hormone (TRH) stimulation tests are used for sensitive thyroid function assessment.
Purpose:
- To investigate the prevalence of mild hypothyroidism in infertile women.
- To assess the relationship between thyroid function, prolactin levels, and ovulatory dysfunction.
- To evaluate the effect of levothyroxine treatment on reproductive parameters.
Summary:
- A TRH stimulation test was performed on 304 infertile women, revealing mild or subclinical hypothyroidism in 12.2%.
- These women often presented with elevated prolactin, luteal phase defects, anovulation, or symptoms of hyperandrogenism.
- Levothyroxine treatment improved prolactin and testosterone levels, enhanced luteal phase function, and resulted in pregnancies.
Impact:
- Mild hypothyroidism is a potential cause of ovarian insufficiency and infertility.
- Thyroid function assessment should be a routine part of evaluating infertile patients, especially those with hyperprolactinemia or anovulation.
- Timely diagnosis and treatment of hypothyroidism can improve fertility outcomes.