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Updated: Apr 26, 2026

Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Metabolic disturbances in diseases with neurological involvement
João M N Duarte1, Patrícia F Schuck2, Gary L Wenk3
1Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Switzerland.
Abstract:
Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria and glutaric aciduria type I. The involvement of mitochondrial dysfunction in these diseases was reported, elicited by genetic alterations, exogenous toxins or buildup of toxic metabolites. In this review we shall discuss some metabolic alterations related to the pathophysiology of diseases with neurological involvement and aging process. These findings may help identifying early disease biomarkers and lead to more effective therapies to improve the quality of life of the patients affected by these devastating illnesses.
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