Alcohol abuse and ERP components in Go/No-go tasks using alcohol-related stimuli: impact of alcohol avoidance

Alcohol addictive behaviors are associated with a combination of deficits in executive functions, such as a weak response inhibition, and potent automatic appetitive responses to alcohol-related cues. The aim of the present study was to investigate behavioral responses and event-related potentials (ERPs) associated with specific response inhibition for alcohol-related cues. Thirty participants (15 heavy drinkers and 15 light drinkers) took part in the study. Response inhibition was assessed by a classical letter Go/No-go task and by a modified alcohol Go/No-go task. Participants were also classified as high and low alcohol avoiders. Results showed that heavy drinkers made more false alarms in the letter Go/No-go task. In the alcohol Go/No-go task, an absence of N200 amplitude anteriorization was found in heavy drinkers as compared to light drinkers. Participants with a high level of alcohol avoidance exhibited more false alarms, and higher N200 amplitude for the No-go trials as compared to the Go trials for alcohol-related cues. Higher P300 amplitude was observed in low alcohol avoiders for No-go as compared to Go trials. Therefore, a context involving alcohol-related cues disturbed inhibition capacities of high alcohol avoiders. These results suggest that the level of alcohol avoidance must be taken into account in studies investigating alcohol-related cognitive biases.