Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Process Parameters and Process Defects on the Flexural Fatigue Life of Ti-6Al-4V Fabricated by Laser Powder Bed Fusion.

Materials (Basel, Switzerland)·2024
Same author

Effect of Layer Thickness and Heat Treatment on Microstructure and Mechanical Properties of Alloy 625 Manufactured by Electron Beam Powder Bed Fusion.

Materials (Basel, Switzerland)·2022
Same author

Investigation of Microstructure and Mechanical Properties for Ti-6Al-4V Alloy Parts Produced Using Non-Spherical Precursor Powder by Laser Powder Bed Fusion.

Materials (Basel, Switzerland)·2021
Same author

The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration.

Bioactive materials·2020
Same author

Effects of Postprocess Hot Isostatic Pressing Treatments on the Mechanical Performance of EBM Fabricated TI-6Al-2Sn-4Zr-2Mo.

Materials (Basel, Switzerland)·2020
Same author

Favorable modulation of osteoblast cellular activity on Zr-modified Co-Cr-Mo alloy: The significant impact of zirconium on cell-substrate interactions.

Journal of biomedical materials research. Part B, Applied biomaterials·2019

Related Experiment Video

Updated: Apr 26, 2026

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

9.2K

Interplay between cellular activity and three-dimensional scaffold-cell constructs with different foam structure

Krishna C Nune1, R Devesh K Misra, Sara M Gaytan

  • 1Biomaterials and Biomedical Engineering Research Laboratory, Center for Structural and Functional Materials, Institute for Materials Research and Innovation, University of Louisiana at Lafayette, Lafayette, Louisiana, 70504.

Journal of Biomedical Materials Research. Part A
|August 12, 2014
PubMed
Summary

This study shows that interconnected 3D foamed scaffolds enhance cell activity, promoting osteoblast differentiation and extracellular matrix mineralization for better tissue integration.

Keywords:
Ti-6Al-4V alloyfoamed structuremineralizationosteoblast functions

More Related Videos

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms
11:19

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Published on: April 11, 2017

15.9K
Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
09:37

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

11.3K

Related Experiment Videos

Last Updated: Apr 26, 2026

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

9.2K
Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms
11:19

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Published on: April 11, 2017

15.9K
Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
09:37

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

11.3K

Area of Science:

  • Biomaterials Science
  • Cellular Biology
  • Tissue Engineering

Background:

  • Cell adhesion, proliferation, and biomineralization are crucial for scaffold-cell construct integration.
  • Understanding the interplay between cellular activity and scaffold architecture is key for regenerative medicine.

Purpose of the Study:

  • To elucidate the relationship between cellular activity and a novel 3D foamed scaffold architecture.
  • To explore the organization of key proteins (actin, vinculin, fibronectin) within the scaffold.
  • To investigate how scaffold structure influences cell behavior and extracellular matrix (ECM) formation.

Main Methods:

  • Combining cellular biology, materials science, and engineering.
  • Utilizing electron beam melting for scaffold fabrication.
  • Employing computational tools for analysis.
  • Investigating protein organization (actin, vinculin, fibronectin) and cellular responses.

Main Results:

  • The interconnected 3D foamed structure with ligaments supported cell attachment, proliferation, and differentiation.
  • The scaffold architecture facilitated cell migration and communication, enhancing osteoblast differentiation.
  • Filopodial interactions among cells on ligaments governed ECM secretion, maturation, and mineralization.

Conclusions:

  • Interconnected 3D foamed scaffolds promote favorable cellular functions, including enhanced ECM mineralization.
  • Scaffold architecture plays a critical role in modulating cell behavior and tissue integration.
  • This study provides fundamental insights into scaffold-cell interactions for tissue engineering applications.