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High prevalence of antineuronal antibodies in Tunisian psychiatric inpatients

Lilia Laadhar1, Oussama Sidhom, Mondher Zitouni

  • 1From the Dept. of Immunology, Al Rabta Hospital, Tunis, Tunisia (LL, NS, MZ, HL, MKS, SM); and Research Unit 03/04 "Schizophrenias," Dept. of Psychiatry F, Al Razi Mental Health Hospital, Mannouba, Tunisia (OS, WA, ZEH).

The Journal of Neuropsychiatry and Clinical Neurosciences
|August 12, 2014
PubMed

The authors aimed to determine the prevalence of antineuronal antibodies in 103 psychiatric inpatients and 41 control subjects with no history of malignancies or neurological disorders. All sera were tested by indirect immunofluorescence and positive sera by immunoblot. Using immunofluorescence, antineuronal nuclear autoantibodies were detected in 20 patients and none of the control subjects, and antibodies reacted with the cytoplasm of Purkinje cells in six patients and two control subjects. The immunoblot confirmed well-characterized antineuronal antibodies only in five patients: two had anti-Ri and three had anti-Yo antibodies. After a follow-up of 5 years, none of these patients developed neurological disorder or malignancy.

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