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Diagnostic usefulness of quantitative tissue velocity imaging and anatomic M-mode echocardiography for coronary
Shaoqi Chen1, Xiaoxia Chen1, Baoqun Zheng1
1Department of Ultrasound, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, 515041, China.
Insights
Quantitative tissue velocity imaging and M-mode echocardiography can help diagnose coronary artery disease (CAD). Mid-segment ventricular wall-thickening fraction shows high sensitivity and specificity for CAD evaluation.
Area of Science:
- Cardiology
- Medical Imaging
- Diagnostic Techniques
Background:
- Coronary artery disease (CAD) diagnosis relies on various imaging modalities.
- Quantitative tissue velocity imaging and M-mode echocardiography offer potential for assessing myocardial function.
Purpose of the Study:
- To evaluate the clinical utility of quantitative tissue velocity imaging and anatomic M-mode echocardiography.
- To establish optimal diagnostic criteria for these echocardiographic methods in patients with suspected CAD.
Main Methods:
- 44 subjects with suspected CAD underwent quantitative tissue velocity imaging and M-mode echocardiography.
- Subjects were classified as patients (stenosis ≥ 50%) or controls (normal angiography).
- Receiver-operator curves were used to assess diagnostic criteria, sensitivity, and specificity.
Main Results:
- Patients with CAD exhibited significantly lower systolic myocardial velocity and ventricular wall-thickening fraction compared to controls.
- Mid-segment ventricular wall-thickening fraction demonstrated 95% sensitivity and 98.3% specificity for CAD detection.
- Systolic myocardial velocity showed 83% sensitivity and 90% specificity, while the combination achieved 97% sensitivity.
Conclusions:
- Mid-segment ventricular wall-thickening fraction is a promising metric for evaluating patients with coronary artery disease.
- Echocardiographic assessment of myocardial mechanics can aid in CAD diagnosis.
Background And Objective:
To explore the potential clinical usefulness and determine optimal diagnostic criteria of quantitative tissue velocity imaging and anatomic M-mode echocardiography in patients with coronary artery disease (CAD).
Methods:
We used quantitative tissue velocity imaging for the measurement of systolic myocardial velocity, and anatomic M-mode echocardiography for the measurement of ventricular wall-thickening fraction in 44 subjects with suspected CAD. Subjects were classified as patients if coronary angiography demonstrated a stenosis ≥ 50%, and as controls if it was strictly normal. The diagnostic criteria, sensitivity, and specificity were assessed by receiver-operator curves.
Results:
Controls had greater mean systolic myocardial velocity and ventricular wall-thickening fraction in the basal (6.59 ± 1.25 cm/s and 0.44 ± 0.05) and mid segment (5.23 ± 0.93 cm/s and 0.43 ± 0.04) than patients (5.02 ± 1.17 cm/s and 0.29 ± 0.04, 3.27 ± 1.29 cm/s and 0.29 ± 0.04, respectively, p < 0.001). Mid-segment ventricular wall-thickening fraction offered 95% sensitivity (95% CI 88.7% to 98.4%), and 98.3% specificity (95% CI 90.9% to 1.0) with an optimal cut-off point of 0.349, yielding better results than systolic myocardial velocity, which provided 83% sensitivity (95% CI 74.2% to 89.8%), 90% specificity (95% CI 79.5% to 96.2%), and optimal cut-off point 4.47. The combination of systolic myocardial velocity and ventricular wall-thickening fraction offered 97% sensitivity (95% CI 91.5% to 99.4%)
Conclusions:
Mid-segment ventricular wall-thickening fraction might be suitable for the evaluation of patients with CAD.
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