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Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol
Published on: September 21, 2021
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Tryptophan supplementation and postoperative delirium--a randomized controlled trial
Thomas N Robinson1, Christina L Dunn, Jill C Adams
1Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Surgery, Denver Veteran's Affairs Medical Center, Denver, Colorado.
Journal of the American Geriatrics Society
|August 13, 2014
Summary
Postoperative tryptophan supplementation did not reduce the incidence or duration of delirium in elderly surgical patients. This randomized trial found no significant benefit for preventing excitatory or overall postoperative delirium.
Area of Science:
- Geriatric Medicine
- Anesthesiology
- Neuroscience
Background:
- Postoperative delirium is a common complication in elderly patients undergoing major surgery.
- Identifying effective preventative strategies is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the efficacy of L-tryptophan supplementation in preventing postoperative delirium in older adults.
- To assess the impact of tryptophan on both excitatory and overall delirium.
Main Methods:
- A randomized, double-blind, placebo-controlled trial was conducted with 325 participants aged 60 and older.
- Participants received either L-tryptophan (1g TID) or placebo postoperatively for up to 3 days.
- Delirium was assessed using the Confusion Assessment Method-Intensive Care Unit (CAM-ICU) and Richmond Agitation and Sedation Scale.
Main Results:
- The overall incidence of postoperative delirium was 39%.
- Tryptophan supplementation did not significantly reduce the incidence or duration of excitatory delirium (17% vs 9%) or overall delirium (40% vs 37%) compared to placebo.
- No statistically significant differences were observed in delirium duration between the groups.
Conclusions:
- Postoperative L-tryptophan supplementation is not effective in reducing the incidence or duration of delirium in elderly patients undergoing major surgery.
- Further research may be needed to explore alternative interventions for preventing postoperative delirium.
