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Related Experiment Video

Updated: Apr 26, 2026

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Published on: February 24, 2021

Functional connectivity in rat brain at 200 μm resolution.

James S Hyde¹, Rupeng Li

¹Department of Biophysics, Medical College of Wisconsin , Milwaukee, Wisconsin.

Brain Connectivity

|August 13, 2014

Summary

This study used high-resolution functional magnetic resonance imaging (fMRI) in rats to map brain responses to touch. Researchers identified specific activated regions and explored their complex connectivity patterns within the sensorimotor cortex.

Keywords:

functional connectivity MRI (fcMRI)functional magnetic resonance imaging (fMRI)rat brain anatomy whisker barrel

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Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

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Last Updated: Apr 26, 2026

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Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Area of Science:

Neuroscience
Neuroimaging
Somatosensory System

Background:

Understanding the brain's response to sensory input is crucial for neuroscience.
Functional magnetic resonance imaging (fMRI) allows non-invasive visualization of brain activity.

Purpose of the Study:

To investigate the somatosensory fMRI response to electrical stimulation of a rat's digit.
To map functional connectivity within the rat sensorimotor cortex at high resolution.

Main Methods:

Utilized high-resolution (200 μm cubic) 9.4 T fMRI in four rats.
Applied electrical stimulation to the middle phalange of the second digit.
Employed functional connectivity fMRI (fcMRI) to analyze voxel interdependencies.

Main Results:

High-threshold activation localized to a penetrating vein and a single cortical column in the forepaw barrel subfield (FBS).
Robust activation observed in the indusium griseum (IG).
Decreasing thresholds revealed spreading connectivity to S2, M1/M2, and contralateral S1 areas, indicating complex patterns potentially involving association fibers.

Conclusions:

High-resolution fMRI successfully mapped somatosensory responses and functional connectivity in the rat brain.
The study highlights complex connectivity patterns within the sensorimotor cortex, with S2 and IG showing extensive and regionally varied connections.
Observed connectivity beyond the typical region of sensitivity suggests an extended volume of observable tissue.