Long non-coding RNAs in cancer: implications for personalized therapy

Area of Science:

• Molecular Biology
• Oncology
• Genetics

Background:

• Long non-coding RNAs (lncRNAs), pseudogenes, and circular RNAs (circRNAs) are emerging as significant factors in cancer biology.
• Their roles in cancer pathogenesis are increasingly recognized, highlighting their potential impact on personalized cancer medicine.

Purpose of the Study:

• To review the roles of lncRNAs, pseudogenes, and circRNAs in cancer.
• To discuss their utility as diagnostic and prognostic biomarkers.
• To explore their potential as therapeutic targets and drugs in clinical practice.

Main Methods:

• Literature review of recent studies on lncRNAs, pseudogenes, and circRNAs in cancer.
• Analysis of their applications in diagnostics, prognostics, and therapeutics.
• Discussion of current limitations for clinical translation.

Main Results:

• lncRNAs, pseudogenes, and circRNAs are implicated in various aspects of cancer development and progression.
• These non-coding RNAs demonstrate potential as reliable biomarkers for cancer diagnosis and prognosis.
• They also present opportunities for targeted cancer therapies and drug development.

Conclusions:

• lncRNAs, pseudogenes, and circRNAs hold significant promise for advancing personalized cancer medicine.
• Further research and development are needed to overcome existing limitations for their widespread clinical adoption.