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Factors modifying valproate plasma level/dose ratio: age, sex, dose and plasma level
A Sánchez1, J A Durán, J A Abadín
1Clinical Pharmacology Department, University Hospital, School of Medicine, Seville, Spain.
Methods and Findings in Experimental and Clinical Pharmacology
|September 1, 1989
Abstract:
Valproate plasma level/dose (L/D) ratios obtained from 155 outpatients under long-term monotherapeutic regimen have been studied. Analytical data were obtained by enzymatic immunoassay (EMIT) from paired samples taken before the morning drug dosage. L/D ratios were increased with age and plasma level and decreased with dose. There were no sex differences in L/D in the different age, dose and concentration groups. L/D ratios were higher than those found by other researchers in our country.