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Updated: Apr 26, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
Published on: September 13, 2022
Development of aptamer oligonucleotides as anticoagulants and antithrombotics for cardiovascular diseases: current
Weibin Li1, Kaiyu Wang2, Meng Zhao2
1Second Military Medical University, Shanghai 200438, China; Institute for Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Command, No 156 North Xi-er Huan Road, Fuzhou City, Fujian Province, 350025, China.
Abstract:
Aptamers are short DNA/RNA oligonucleotides selected by a process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) based on affinity for target molecules. Since aptamers have several advantages over monoclonal antibodies, such as high specificity and affinity, flexible modification and stability, and lack of toxicity and immunogenicity, they are promising novel diagnostic and therapeutic agents. In this review, we will describe the development of aptamers against thrombin, von Willebrand factor (vWF), factor IX, and factor XII as potential anticoagulants or antithrombotics for cardiovascular diseases, especially those that have entered clinical trials.
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