Reducing the risk of harm from medication errors in children

Daniel R Neuspiel1, Melissa M Taylor2

  • 1Levine Children's Hospital of Carolinas Medical Center, Charlotte, NC, USA. ; University of North Carolina School of Medicine, Charlotte, NC, USA.

Health Services Insights
|August 13, 2014
PubMed

Insights

Pediatric medication errors pose risks across all care settings. Strategies like e-prescribing and improved labeling aim to reduce these adverse drug events in children.

Area of Science:

  • Pediatric patient safety
  • Medication error prevention
  • Health systems quality improvement

Background:

  • Pediatric patients face unique risks for medication errors due to physiological variability and communication challenges.
  • Children with chronic conditions on multiple medications are particularly vulnerable to adverse drug events.
  • Medication errors occur in various settings, including outpatient, inpatient, emergency departments, and home environments.

Purpose of the Study:

  • To review strategies employed to mitigate pediatric medication errors.
  • To highlight areas requiring further research in pediatric patient safety.

Main Methods:

  • Review of existing literature and implemented strategies for pediatric medication error reduction.
  • Identification of common risk factors and preventive measures in pediatric care.

Main Results:

  • Multiple strategies are in use, including e-prescribing, computerized provider order entry with decision support, medication reconciliation, and barcode systems.
  • Interventions also involve clinical pharmacists, staff training, packaging improvements, standardized labeling, and home administration devices.
  • Quality improvement initiatives focus on nonpunitive error reporting and systemic changes.

Conclusions:

  • A multi-faceted approach is necessary to address pediatric medication errors.
  • Further research is essential to validate the effectiveness of implemented preventive strategies.
Abstract

Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
116
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
399
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
544
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
1.0K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
954
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
405