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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Methicillin-resistant Staphylococcus aureus infection: an independent risk factor for mortality in patients with

Serap Simşek Yavuz1, Ayfer Sensoy, Sabahat Ceken

  • 1Department of Infectious Diseases and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|August 14, 2014
PubMed
Abstract

Insights

Poststernotomy mediastinitis has a high mortality rate. Eliminating methicillin-resistant Staphylococcus aureus (MRSA) significantly reduced patient deaths, highlighting infection control importance.

Area of Science:

  • Cardiovascular Surgery
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Poststernotomy mediastinitis presents a significant challenge with a high mortality rate.
  • Identifying key risk factors is crucial for improving patient outcomes.

Purpose of the Study:

  • To identify independent risk factors associated with mortality in patients diagnosed with poststernotomy mediastinitis.
  • To evaluate the impact of infection control measures on mortality rates.

Main Methods:

  • A surveillance study of adult patients undergoing sternotomy between 2004 and 2012.
  • Diagnosis of mediastinitis based on US Centers for Disease Control and Prevention criteria.
  • Statistical analysis of hospital database records to determine mortality risk factors.

Main Results:

  • The incidence of poststernotomy mediastinitis was 0.39% (117/19,767 patients), with a 32% mortality rate.
  • Independent mortality risk factors included methicillin-resistant Staphylococcus aureus (MRSA) infection, intensive care unit stays exceeding 48 hours, and valve replacement surgery.
  • Mortality rates significantly decreased from 38% (2004-2008) to 14% (2009-2012), correlating with MRSA elimination efforts.

Conclusions:

  • Elimination of MRSA in the hospital setting was associated with a significant decrease in mortality for poststernotomy mediastinitis patients.
  • Effective infection control strategies, particularly targeting MRSA, are vital for reducing mortality in this patient population.

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