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Reduced Protein C Activity Might be Associated With Progression of Peripheral Arterial Disease

Hiroyoshi Komai1, Shunya Shindo2, Masahiro Sato2

  • 1Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Moriguchi, Osaka, Japan komaihir@takii.kmu.ac.jp.

Angiology
|August 14, 2014
PubMed

Insights

Reduced protein C (PC) and protein S (PS) activity is more common in peripheral arterial disease (PAD) patients. Lower PC activity independently predicts critical limb ischemia (CLI) progression in PAD.

Area of Science:

  • Vascular Biology
  • Hematology
  • Coagulation Disorders

Background:

  • Peripheral arterial disease (PAD) is a significant vascular condition.
  • Protein C (PC) and Protein S (PS) are crucial anticoagulants.
  • Understanding risk factors for PAD progression, especially critical limb ischemia (CLI), is vital.

Purpose of the Study:

  • To investigate the association between reduced protein C (PC) and protein S (PS) activity and the progression of peripheral arterial disease (PAD).
  • To determine if PC and PS deficiencies are risk factors for critical limb ischemia (CLI) in PAD patients.

Main Methods:

  • Measured PC and PS activities in 106 PAD patients and 44 abdominal aortic aneurysm (AAA) patients.
  • Compared PC and PS levels between PAD patients with critical limb ischemia (CLI) and intermittent claudication.
  • Utilized multivariate logistic regression analysis to identify determinant factors for CLI.

Main Results:

  • Incidences of PC deficiency (4.7% in PAD, 4.5% in AAA) and PS deficiency (14.1% in PAD, 11.4% in AAA) were higher than in the general population.
  • PC and PS activities were significantly lower in patients with critical limb ischemia (CLI) compared to those with intermittent claudication.
  • Lower PC activity and female gender were identified as independent predictors for CLI development in multivariate analysis.

Conclusions:

  • Reduced protein C (PC) and protein S (PS) activity is prevalent in patients with peripheral arterial disease (PAD).
  • Protein C (PC) deficiency is an independent predictor for the progression of critical limb ischemia (CLI) in PAD patients.
  • These findings highlight the potential role of coagulation factor deficiencies in PAD pathogenesis and progression.

Keywords:
abdominal aortic aneurysmcritical limb ischemiahypercoagulabilityperipheral arterial diseaseprotein Cprotein S

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