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Bioactive constituents from Croton sparsiflorus Morong
Durre Shahwar1, Naeem Ahmad, Asma Yasmeen
1a Research Lab. II, Department of Chemistry , Government College University , Lahore 54000 , Pakistan.
Natural Product Research
|August 14, 2014
Summary
Croton sparsiflorus extracts yield potent antioxidant and enzyme-inhibiting compounds. These noraporphine alkaloids, crotsparinine, crotsparine, and sparsiflorine, validate traditional uses and may treat gout and neurodegenerative diseases.
Area of Science:
- Phytochemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Croton sparsiflorus is traditionally used for rheumatic conditions.
- Whole plant extracts exhibit notable enzyme inhibition and antioxidant properties.
Purpose of the Study:
- To isolate and characterize bioactive compounds from Croton sparsiflorus.
- To evaluate the enzyme inhibitory and antioxidant potential of isolated compounds.
Main Methods:
- Bioassay-guided fractionation of methanol extracts.
- Isolation and structural elucidation using spectral analyses (EI-MS, NMR).
- Enzyme inhibition assays (xanthine oxidase, acetylcholine esterase) and antioxidant assays (DPPH, FRAP).
Main Results:
- Three noraporphine alkaloids, crotsparinine (1), crotsparine (2), and sparsiflorine (3), were isolated.
- Compounds 1-3 demonstrated significant inhibition of xanthine oxidase and acetylcholine esterase.
- Potent radical scavenging and reducing activities were observed for compounds 1-3.
Conclusions:
- The isolated compounds validate the ethnomedicinal use of C. sparsiflorus for gout and rheumatism.
- Noraporphine alkaloids from C. sparsiflorus show potential for treating neurodegenerative diseases.
