Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Structure01:55

Bone Structure

40.3K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
40.3K
Bone Remodeling01:40

Bone Remodeling

34.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calcium-Deficient hydroxyapatite as a bone graft material: From hydrated-layer chemistry to clinical performance.

Acta biomaterialia·2026
Same author

Comparison of musculoskeletal responses and its variability after long-term spaceflight and prolonged bed rest conditions.

NPJ microgravity·2026
Same author

ESA VIVALDI (1 & 2) campaigns: sex-specific bone responses to dry immersion-induced unloading.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Sex-specific cardiometabolic responses during microgravity simulation in European Space Agency VIVALDI dry immersion.

Communications medicine·2026
Same author

Quantitative Ultrasound Imaging of Bone: Anatomical Images, Tissue Structural Quality, and Pulsatile Blood Flow.

IEEE transactions on medical imaging·2026
Same author

Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit.

NPJ microgravity·2025

Related Experiment Video

Updated: Apr 25, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

6.7K

In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment.

Guenaelle Bouet1, David Marchat, Magali Cruel

  • 11 Laboratoire de Biologie du Tissu Osseux, Institut National de la Santé et de la Recherche Médicale-U1059, Université de Lyon-Université Jean Monnet , Saint-Etienne, France .

Tissue Engineering. Part B, Reviews
|August 14, 2014
PubMed
Summary

Three-dimensional (3D) culture systems offer a more accurate in vitro model for bone biology research than traditional 2D cultures. These advanced systems better mimic the in vivo bone environment for improved physiological understanding.

More Related Videos

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

4.3K
A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
08:51

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

Published on: March 8, 2014

15.8K

Related Experiment Videos

Last Updated: Apr 25, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

6.7K
A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

4.3K
A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
08:51

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

Published on: March 8, 2014

15.8K

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • Traditional 2D cell cultures on polystyrene lack the complexity of the in vivo bone environment.
  • Monolayer cultures do not accurately replicate the dynamic biophysical, biochemical, and biomechanical cues crucial for bone cell physiology.

Purpose of the Study:

  • To review the state-of-the-art and advances in 3D culture systems for bone biology research.
  • To highlight the advantages and challenges of using these systems.
  • To discuss future directions in noninvasive imaging for 3D bone cultures.

Main Methods:

  • Review of current literature on 3D bone culture systems.
  • Analysis of scaffold materials, cell sources, and perfusion bioreactor technologies.
  • Discussion of imaging techniques for monitoring 3D cultures.

Main Results:

  • 3D culture systems provide a more physiologically relevant in vitro model for bone research.
  • Key components like scaffolds, cells, and bioreactors present specific advantages and challenges.
  • Noninvasive imaging technologies are crucial for future advancements.

Conclusions:

  • 3D culture systems are essential for advancing our understanding of bone cell physiology.
  • Optimizing scaffolds, cell integration, and bioreactor perfusion is critical.
  • Development of advanced noninvasive imaging is needed for comprehensive monitoring.