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Limb apraxia and verb processing in Alzheimer's disease
Maria Cotelli1, Rosa Manenti, Michela Brambilla
1a IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli , Brescia , Italy.
Journal of Clinical and Experimental Neuropsychology
|August 14, 2014
Summary
Alzheimer's disease patients show linked language and praxis deficits. Impaired verb production specifically impacts action comprehension, suggesting a shared cognitive decline in Alzheimer's disease.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Neurology
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
- AD significantly impacts cognitive functions, including language and motor skills.
- The relationship between language and praxis deficits in AD requires further investigation.
Purpose of the Study:
- To investigate the relationship between language and praxis abilities in Alzheimer's disease patients.
- To compare linguistic and praxic performance between AD patients and a control group.
- To explore action comprehension in AD using the Action Sequence Comprehension task.
Main Methods:
- Experimental evaluation comparing AD patients and controls.
- Assessment of linguistic abilities: verb/noun naming, sentence comprehension.
- Assessment of praxic abilities: gesture execution, action comprehension (Action Sequence Comprehension).
Main Results:
- A direct relationship was found between language impairment and apraxia in AD patients.
- Both language and action production/comprehension were equally impaired in AD.
- Action semantics comprehension correlated more with verb production than noun production.
Conclusions:
- Language and praxis deficits are interconnected in Alzheimer's disease.
- AD presents a spectrum of concomitant linguistic and praxis impairments.
- Verb production is a key factor in action comprehension within the context of AD.
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