[Evaluation of the antianginal efficacy of sustonit compared with other nitrate drug forms]

Sustonite, a long-acting nitroglycerin drug for oral use (manufactured in Poland), and some other dosage forms of nitrates were studied and compared. Twenty-one patients with stable angina pectoris of effort, functional classes II-III, were entered into the study. Sustonite was shown to produce an antianginal effect slightly yielding to that of sustac administered in equivalent doses. As to the effectiveness, sustonite appeared inferior to the dosage forms of nitrates such as nitrosorbide tablets, trinitrolong and dinitrosorbilong plates. The effect of sustonite manifested itself much later than that of sustac. As regards the physicochemical properties, sustonite tablets materially differ from sustac tablets in disintegration and solubility which are worse. The content of nitroglycerin in the tablets has turned out lower (1.2-1.4-fold) as compared to that indicated by the manufacturer.